KPV 10mg

KPV (Lys-Pro-Val) is a naturally occurring C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (alpha-MSH). It is one of the smallest bioactive peptide fragments known in the melanocortin system.

Research has established that KPV is actively transported into intestinal epithelial and immune cells via the PepT1 transporter, which is upregulated in inflamed tissue. At nanomolar concentrations, KPV has been shown to inhibit NF-kB and MAP kinase inflammatory signalling pathways and significantly reduce pro-inflammatory cytokine secretion in cell culture models.

Preclinical studies have investigated KPV across models of intestinal inflammation, pulmonary inflammation, and dermal inflammatory conditions. Identified mechanisms include interaction with the melanocortin-3 receptor (MC3R), inhibition of NF-kB nuclear translocation, and reduction of macrophage recruitment and chemokine signalling.

Research has also focused on delivery challenges. Unmodified KPV degrades to its three constituent amino acids within approximately 24 hours. Studies have explored nanoparticle encapsulation, glycoalkylation, and iontophoretic delivery methods to improve metabolic stability and tissue targeting.

For In-Vitro Research Use Only. Not for human consumption, veterinary use, or clinical application. No dosing guidance is provided or implied.