NAD+ 500mg

NAD+ (Nicotinamide Adenine Dinucleotide) is an endogenous pyridine nucleotide present in all living cells. It functions as a central redox cofactor and signalling molecule in cellular metabolism, alternating between its oxidised (NAD⁺) and reduced (NADH) forms to transfer electrons in fundamental metabolic pathways including glycolysis, the tricarboxylic acid cycle, and oxidative phosphorylation.

Beyond its role as an electron carrier, NAD+ serves as a consumed substrate for several enzyme families of significant research interest. Sirtuins (SIRT1-7) are NAD+-dependent deacetylases that link cellular energy status to chromatin structure, gene expression, and metabolic regulation. Poly(ADP-ribose) polymerases (PARPs) consume NAD+ during DNA damage repair responses. Cyclic ADP-ribose synthases (CD38/CD157) use NAD+ to generate calcium-mobilising second messengers.

Cellular NAD+ levels decline with age across multiple tissues and model organisms. A landmark 2013 study published in Cell demonstrated that raising NAD+ levels in aged mice restored mitochondrial function to levels resembling young animals through a SIRT1-dependent mechanism, identifying disrupted nuclear-mitochondrial communication driven by NAD+ depletion as a contributor to age-associated mitochondrial dysfunction.

Research into NAD+ precursor supplementation (NR, NMN) and direct NAD+ repletion has expanded significantly, with investigations spanning metabolic disease, neurodegeneration, cardiovascular function, and cellular senescence. A 2021 review in Nature Reviews Molecular Cell Biology comprehensively mapped NAD+ metabolism and its roles in cellular processes during ageing.

This product is supplied as the oxidised form (NAD⁺), suitable for in-vitro biochemical and cell-based assay systems investigating redox balance, cofactor-dependent enzymatic activity, and NAD+-dependent signalling pathways.

Purity: 99.58% (HPLC verified). Fill weight: 494mg per vial. Certificate of Analysis available.

⚗ For In-Vitro Research Use Only. Not for human consumption, veterinary use, or clinical application. No dosing guidance is provided or implied.